Abstract: The microvascular density is significantly associated with tumour metastasis and organ fibrosis, angiogenesis can be the common target for the therapy of tumor and organ fibrosis. However, traditional anti-angiogenesis strategies attempt to reduce the tumour vascular supply, but their success is restricted by insufficient efficacy or development of resistance. Moreover, the potential angiogenic therapies with the primary aim of ameliorating interstitial fibrosis is falling into bottleneck. Because it is strongly associated with inflammation and changes in vascular permeability. In this review, we will provide a brief review of current understanding of endothelial cell metabolism and vascular niche to understand the underlying relationship between tumor progression and organ fibrosis in angiogenesis.

Key words: Angiogenesis, neoplasms, fibrosis, Matrix metalloproteinases (MMPs), RECK, vascular endothelial cell