Abstract: Objective To evaluate potential association between human GP78 gene and coronary heart disease(CHD). Methods The genotype was analyzed with by a Real-time PCR instrument in CHD group ( n = 557) and control group ( n=552).The data were evaluated via case control study. Results The distribution of rs2617849 genotype and allele frequency showed significant difference between CHD and control subjects( P < 0. 05) ,the distribution of the TT genotype and T allele was significantly higher in CHD patients than control subjects( P < 0. 05) .The significance of the TT genotype between CHD patients and control subjects retained after adjustment for covariates ( 95% CI: 1.035 ～1.736，P <0. 05 ). Conclusion rs2617849 polymorphism is closely associated with CHD，TT genotype and T allele of rs2617849 functions as a genetic markers of CHD．

Key words: Key words:GP78, single nucleotide polymorphism, case- control study, coronary heart disease