Abstract: Recombination Activating Gene(RAG) plays an important role in diverse and complex DNA recombination of B cell antigen-receptor determining regions. The possible mechanisms of RAG genes inducing B cell lymphoma is explained in four aspects as follows: 1)RAG complex can recognize and cut the main breaking region of Bcl-2 gene which will lead the translocation of t(14,18) and promote the lymphoma; 2)the synergy effect between RAG-1/2 genes and AID also induce the translocation of chromosome; 3)extraordinary of V(D)J recombination because of the abnormal degradation of RAG2 protein; 4)EBNA-1 expressing in EBV infected mice may induce the re-expression of RAG1/2 genes.

Key words: Recombination Activating Gene (RAG), lymphoma, rearrangement, translocation, EB virus