Abstract: Mismatch repair (MMR) is a critical mechanism for maintaining microsatellite stability through the correction of base substitution mismatches and insertion/deletion events. Dysfunction of this system will lead to microsatellite stability (MSI), or mutated genes that code functional proteins, thus give rise to cancer. Here we will give an overview for the MMR and the molecular mechanism of related clinical cancer.

Key words: MMR MSI, HNPCC (CRC), Breast cancer, Prostate cancer, Glioma